There continues to be great interest around the world regarding how to build innovation clusters. Inspired by a similar presentation that Fred Wilson did on the NYC start-up scene many years ago, I pulled this presentation together. I just updated it for a group of Harvard Business School students and was struck by how much has changed and progressed in a positive way. I would venture to guess every major US technical hub would say the same. Like Boston, the NYC, SF, Silicon Valley, Boulder and Austin start-up scenes are all on stronger footing and more vibrant and diverse than ever as compared to a few years ago. This should give all of us great optimism for the future.